A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery

Drug-eluting stents have been successful in reducing in-stent restenosis but are not suitable for all lesion types and have been implicated in causing late stent thrombosis due to incomplete regeneration of the endothelial cell layer. In this study we implanted stents coated with cicaprost, a prostacyclin analogue with a long plasma half-life and antiproliferative effects on vascular smooth muscle cells, into the iliac arteries of rabbits. At 28-day follow-up we compared neointima formation within the stented vessels and vascular function in adjacent vessels, to assess if cicaprost could reduce restenosis without impairing vessel function. Arteries implanted with cicaprost eluting stents had significantly more neointima compared to bare metal stents. In adjacent segments of artery, endothelium-dependent relaxation was impaired by the cicaprost-eluting stent but vasodilation to an endothelium-independent vasodilator was maintained. We conclude that the presence of the polymer and sub-optimal release of cicaprost from the stent may be responsible for the increased neointma and impaired functional recovery of the endothelium observed. Further experiments should be aimed at optimising release of cicaprost and exploring different stent polymer coatings

Augmented reality meeting table: a novel multi-user interface for architectural design

Immersive virtual environments have received widespread attention as providing possible replacements for the media and systems that designers traditionally use, as well as, more generally, in providing support for collaborative work. Relatively little attention has been given to date however to the problem of how to merge immersive virtual environments into real world work settings, and so to add to the media at the disposal of the designer and the design team, rather than to replace it. In this paper we report on a research project in which optical see-through augmented reality displays have been developed together with prototype decision support software for architectural and urban design. We suggest that a critical characteristic of multi user augmented reality is its ability to generate visualisations from a first person perspective in which the scale of rendition of the design model follows many of the conventions that designers are used to. Different scales of model appear to allow designers to focus on different aspects of the design under consideration. Augmenting the scene with simulations of pedestrian movement appears to assist both in scale recognition, and in moving from a first person to a third person understanding of the design. This research project is funded by the European Commission IST program (IST-2000-28559)

Bargmann invariants and off-diagonal geometric phases for multi-level quantum systems -- a unitary group approach

We investigate the geometric phases and the Bargmann invariants associated with a multi-level quantum systems. In particular, we show that a full set of `gauge-invariant' objects for an $n$-level system consists of $n$ geometric phases and ${1/2}(n-1)(n-2)$ algebraically independent 4-vertex Bargmann invariants. In the process of establishing this result we develop a canonical form for U(n) matrices which is useful in its own right. We show that the recently discovered `off-diagonal' geometric phases [N. Manini and F. Pistolesi, Phys. Rev. Lett. 8, 3067 (2000)] can be completely analysed in terms of the basic building blocks developed in this work. This result liberates the off-diagonal phases from the assumption of adiabaticity used in arriving at them.Comment: 13 pages, latex, no figure

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death

Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages. Blood platelets are functional anucleate cells generated by specialized fragmentation of their progenitors, megakaryocytes (MKs), but committed to a constitutive caspase-independent death. Constitutive formation of the proplatelet-bearing MK was recently reported to be caspase-dependent, apparently involving mitochondrial release of cytochrome c, a known pro-apoptogenic factor. We extend those studies and report that activation of caspases in MKs, either constitutively or after Fas ligation, yields platelets that are functionally responsive and evade immediate phagocytic clearance, and retain mitochondrial transmembrane potential until constitutive platelet death ensues. Furthermore, the exclusion from the platelet progeny of caspase-9 present in the progenitor accounts for failure of mitochondrial release of cytochrome c to activate caspase-3 during platelet death. Thus, progenitor cell death by apoptosis can result in birth of multiple functional anucleate daughter cells

Two-dimensional constriction flows of foams

International audienceThe flow of a quasi-two-dimensionalfoam through a constriction is described. The bubble velocity and elongation (texture) is compared between two sets of experiments and two different quasi-static simulations using Surface Evolver and Potts model. The simulations capture the effect of changing the degree of rounding of the corners of the flow geometry and the length of the constricted region. Validation of these simulation methods offers the possibility to easily vary many parameters of interest and to explore parameter ranges that are inaccessible to experiments such as low liquid fraction and slow velocity. Perspectives include characterisations of a 3D flow at the bubble scale

A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery

Drug-eluting stents have been successful in reducing in-stent restenosis but are not suitable for all lesion types and have been implicated in causing late stent thrombosis due to incomplete regeneration of the endothelial cell layer. In this study we implanted stents coated with cicaprost, a prostacyclin analogue with a long plasma half-life and antiproliferative effects on vascular smooth muscle cells, into the iliac arteries of rabbits. At 28 day follow-up we compared neointima formation within the stented vessels and vascular function in adjacent vessels, to assess if cicaprost could reduce restenosis without impairing vessel function. Arteries implanted with cicaprost eluting stents had significantly more neointima compared to bare metal stents. In adjacent segments of artery, endothelium-dependent relaxation was impaired by the cicaprost-eluting stent but vasodilation to an endothelium-independent vasodilator was maintained. We conclude that the presence of the polymer and sub-optimal release of cicaprost from the stent may be responsible for the increased neointma and impaired functional recovery of the endothelium observed. Further experiments should be aimed at optimising release of cicaprost and exploring different stent polymer coatings

Can the microbiome drive the suppression of grapevine trunk diseases?

Grapevine trunk diseases (GTDs), caused by several fungal species, are among the most destructive grapevine diseases in New Zealand and other grape-growing countries. The control of the diseases is problematic, and there is currently no approved fungicide for their eradication. This has necessitated seeking alternative strategies, including a sustainable biological control approach, to manage the diseases. Therefore, this study aimed to identify taxa in the grapevine microbiome that contribute to plant health. In some New Zealand vineyards, observations have revealed vines that remain healthy within a background of trunk diseases. These grapevines were termed ‘disease-escape’ to represent their apparent health under heavy disease pressure. Recent research on the grapevine microbiome has shown that microorganisms from these ‘disease-escape’ plants could contribute to disease suppression. Putative disease escape vines were identified in vineyards in two grape-growing regions in New Zealand: Hawke’s Bay and Canterbury. The vines were selected based on their presence in a diseased area, maturity, and absence of trunk disease symptoms. Trunk core samples were taken from the disease-escape vines and neighbouring symptomatic vines. Subsequently, the samples’ total fungal and bacterial communities were identified and compared using culture-independent DNA metabarcoding and culture-dependent approaches. After analysing the metabarcoding and culturing results, microbial taxa that were differentially more abundant in disease-escape grapevines and the ones that correlated negatively with GTD pathogens were identified. The next stage of the study is to design a synthetic community using members of the taxa of interest from the disease-escape grapevines. This SynCom will be introduced into young grapevines and monitored for their ability to suppress the development and severity of GTDs. The research results will provide information on the roles (if any) that the grapevine trunk’s microbiome plays in suppressing GTDs

Interacting anyons in topological quantum liquids: The golden chain

We discuss generalizations of quantum spin Hamiltonians using anyonic degrees of freedom. The simplest model for interacting anyons energetically favors neighboring anyons to fuse into the trivial (`identity') channel, similar to the quantum Heisenberg model favoring neighboring spins to form spin singlets. Numerical simulations of a chain of Fibonacci anyons show that the model is critical with a dynamical critical exponent z=1, and described by a two-dimensional conformal field theory with central charge c=7/10. An exact mapping of the anyonic chain onto the two-dimensional tricritical Ising model is given using the restricted-solid-on-solid (RSOS) representation of the Temperley-Lieb algebra. The gaplessness of the chain is shown to have topological origin.Comment: 5 pages, 4 figure

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